Cholesteryl-TEG is often used to increase the cell uptake of oligonucleotide. This modification has been shown to elicit cell uptake both in vitro and in vivo.
Metabion offers Cholesteryl-TEG in its standard DNA and RNA portfolio. Click here
|MW 5'||683 g/mol|
|MW 3'||756 g/mol|
C. Wolfrum, S. Shi, K.N. Jayaprakash, M. Jayaraman, G. Wang, R.K. Pandey, K.G. Rajeev, T. Nakayama, K. Charrise, E.M. Ndungo, T. Zimmermann, V. Koteliansky, M. Ma. Mechanisms and optimization of in vivo delivery of lipophilic siRNAs. Nature Biotechnology. 25, 2007, 1149 - 1157.