8-Oxo-dG stands for 8-oxo-deoxyguanosine and it consists of an oxidized nucleotide, commonly used to study DNA damage following oxidative stress. In oxidative stress, reactive oxygen species (ROS) damage the DNA, thus creating 8-Oxo-dG “lesions”. 8-Oxo-dGs can create mismatches via pairing with A, thus leading to G ->T transversion. In nature, 8-Oxo-dG does not appear to be highly mutagenic, as the base excision repair system usually restores 8-Oxo-dG to native G.
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|Extinction coefficient (260 nm)||5.9 mM-1cm-1|
W.L. Neeley, J.M. Essigmann. Mechanisms of formation, genotoxicity, and mutation of guanine oxidation products. Chem. Res. Toxicol.(2006), 19: 491-505.