Metabion
imprint links contact jobs site map home
About Metabion
Products & Services
Support & Solutions
News & Events
Order
 
 
Home > Products & Services > DNA/RNA mid & large scale

Mid and Large Scale Oligonucleotide Synthesis –
Options, Specs, Pricing

  DNA
15-20 bases in length
unmodified
RNA
15-20 bases in length
unmodified
DsiRNA
27mer Dicer subrate siRNA
unmodified
Final Yield Price in €* Price in €* Price in €*
50 mg 1850 3375 6740
100 mg 2405 4750 7790
250 mg 3335 7350 10490
500 mg 4770 10965 15160
1 gram 6500 19085 22970
* All prices are in EUR excluding tax and transport, including metabion’s standard large scale QC package, consisting of an analytical HPLC and Mass Spec trace.

 

General Terms & Specs:

  • 10% flexibility on quantity delivered.
  • Typical turnaround time: 6 to 8 weeks.
  • Delivered oligonucleotides are HPLC purified, desalted (gel filtration/dialysis), sterile filtered and lyophilized as a sodium (Na+) salt.
  • DNA and RNA prices only include either phosphorothioate or phosphodiester linkages.
  • Prices could vary with sequence composition and additional modifications.
  • Please inquire for pricing and availability of modified sequences and oligo lengths outside the ranges listed above.

Additional QC Options (please inquire for pricing):

  • Endotoxin Analysis

    Nota bene:
    • Phosphorothioates and some dyes may inhibit in the mechanism that metabion is using for endotoxin determinations; readings might therefore be less accurate for these molecules.
    • Due to the high affinity of cholesterol towards endotoxins, metabion is currently not able to give a specific endotoxin guarantee for cholesterol modified oligonucleotides, however we aim to achieve an endotoxin level below 4 EU/mg.

Custom QC Package(s):

  • Determination of the sodium (Na+) content of the oligonucleotide.

    Nota bene:
    • This analysis requires at least 20 mg of purified oligonucleotide.
    • Sodium (Na+) analysis may require 10 working days for completion.

  • LC-MS of the oligonucleotide.
  • Custom quality-control methods, developed to order.

 

 
© metabion international AG / metabion GmbH 2010