The solid phase synthesis of RNA fragments is now a widespread technique in Molecular Biology. RNA oligonucleotides are becoming increasingly important in structural studies where they can be used as probes in Northern blotting or for in situ hybridization. In regulation, RNA oligonucleotides have been used in an antisense mode. The role of catalytic RNA (ribozymes and most importantly siRNA) as putative antisense therapeutics has sparked considerable interest in synthetic RNA.
What we offer
Unmodified and modified RNA-oligos from 2 to 80 bases:
RNA-oligos are being used for a variety of complex applications, i. e. structural analysis or stimulation of the immune system, that require high purity.
siRNA:
siRNA has rapidly become a widely used tool for determining gene function and validating potential therapeutic targets both in cell culture and in vivo. With the present rate of progress and most recent animal experiments siRNA is poised to become a new generation of rationally designed drugs. However, this will need sophisticated delivery techniques for the siRNA to reach and enter selected cells and tissues.
Aptamers:
Aptamers are DNA or RNA molecules that have been selected from random pools based on their ability to bind other molecules. Aptamers have been selected which bind to nucleic acid, proteins, small organic compounds and even entire organisms. These molecules have many potential uses in medicine.
Ribozymes/Chimeras:
Catalytic RNA is capable of a broad class of reactions.
We are producing high quality RNA-Oligonucleotides according to your demands. Regular checks by MALDI-MS, monitoring during synthesis and our quality management system ensure our high standards.
If you need a modified RNA-Oligonucleotide or sequences with varying lengths, we are pleased to assist you. Many modifications are available. Due to our clean room production site, our RNA-Oligonucleotides are endotoxin free. Even production under cGMP conditions is possible. If you are planning to go for larger amounts of RNA-Oligonucleotide, we can produce your oligos in midscale amounts.