metabion and BioSpring join forces on therapeutic oligonucleotides
Two of the leading independent German manufacturers of nucleic acids are joining forces on special projects to better serve the growing oligo therapeutic market and assist the discovery path with a seamless supply of Custom GMP grade therapeutic oligonucleotides.
November 11 2025
The long road of custom oligo therapeutic medicine discovery, beginning at research to final therapeutic product, is often hampered by the inability to reliably source oligonucleotides in varying quantities from a single, seamless source of production. This gap can be crippling to projects and create uncertainty for the future of promising drug development plans.
By integrating metabion at the early stages of therapeutic oligonucleotide development and transitioning to BioSpring for scale-up and commercialisation, customers benefit from a structured and uninterrupted workflow. The collaboration allows early-stage innovators to begin with metabion’s focused support in candidate screening and lead discovery seamlessly moving into BioSpring’s robust infrastructure when the project demands it — ensuring continuity, reliability, and speed from the start.
The experience, including regulatory support, and industry leading production capacities of the two independent companies offer this unique compliment to meet the R&D, Clinical & Commercial Phase target market of Germany, Europe and worldwide.
metabion
metabion is a high-quality manufacturer of custom nucleic acids, focused on providing DNA/RNA oligonucleotides including customized solutions for R&D, Diagnostic and Therapeutic applications. The Company is ISO 13485:2016 (equivalent to 21 CFR 820/cGMP Diagnostic), ISO 9001:2015 and EXCiPACT® GMP/GDP:2021 certified. 30 years of successfully translating the highest quality standard into daily practice is the key to deliver sustainable customer success. metabion is located in Munich.
BioSpring
BioSpring is a technology leader in nucleic acid manufacturing and analysis for therapeutic and diagnostic applications. BioSpring specializes in high-quality cGMP manufacturing and analysis, supporting clients through every stage of drug development:
- Early discovery & preclinical development
- Clinical phases I-III
- Commercial market supply
With a team of over 650 dedicated employees, BioSpring clients rely on their comprehensive and customizable solutions designed to accelerate therapeutic programs, ensuring the clients’ innovations reach their full potential. BioSpring is located in Frankfurt am Main.
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