2’MOE-C (Figure 1) stands for 2’-O-methoxyethyl-cytosine. 2’MOE is a sugar modification in nucleic acids that enhances stability, binding affinity, and pharmacological properties. It increases resistance to enzymatic degradation, improves duplex stability, and is widely used in antisense oligonucleotide therapeutics. Per modification, 2'-MOE increases ΔTm by 0.9 to 1.6 °C. Its balance of strong binding and favourable biocompatibility makes it one of the most important modifications in the design of modern therapeutic oligonucleotides.
Figure 1. Structure of 2’MOE-C (R = sequence)
metabion offers this modification as part of its Standard Therapeutic Modifications Portfolio.
Learn more about how we can support your therapeutic oligonucleotide projects here.