Accelerate your drug development with a seamless, integrated workflow for precisely functionalized oligonucleotide therapeutics. By combining metabion’s premier custom oligosynthesis with baseclick’s advanced click-chemistry expertise, we deliver high-purity, targeted therapeutic oligos from research to clinical development.
Integrated Workflow for Click-Functionalized Oligos
This coordinated approach reduces complexity, shortens development timelines, and ensures consistent quality throughout the synthesis and modification process.
Through our partnership, customers benefit from:
- High-Purity Synthesis: Oligonucleotide synthesis by metabion, optimized for click-compatible modifications to enable specific targeting.
- Precision Targeting: Reliable incorporation of site-specific clickable handles.
- Scalable Conjugation: Efficient and scalable click-chemistry conjugation services.
- Flexible Pathways: From research-grade for preclinical studies to advanced development projects for further clinical trials.
- Coordinated Support: Unified technical and scientific support across both companies.
Figure 1. A. Chemical modifications can be conjugated to the oligonucleotide using copper-catalyzed azide–alkyne cycloaddition (CuAAC) or strain-promoted azide–alkyne cycloaddition (SPAAC) click chemistry. B. Incorporation of a linker can enhance molecular stability and promote optimal spatial orientation of the ligand. C. Sugar modifications enable receptor-specific binding on the target organ, facilitating cellular uptake via receptor-mediated endocytosis.
Simplified Ordering and Direct Access
To streamline project initiation, pathways are optimized for siRNA and ASO requests. Customers can easily prepare and submit custom synthesis requests through our connected channels:
- Prepare: Download and complete the custom synthesis order form for siRNA and ASO.
- Submit via metabion: Send the completed order form directly to sales@metabion.com.
- Submit via baseclick: Alternatively, submit the order form directly in the baseclick webshop.
If the ligand you wish to use is not listed in the template, please get in touch and discuss further ligand options, depending on disease indication or target organ.
Our scientific teams are available to support you in your endeavours to develop your therapeutic strategies. For tailored project discussions or technical inquiries, please reach out to our experts.