Explore our therapeutic oligonucleotide portfolio, combining custom synthesis, advanced modifications, quality assessment, and the possibility to scale up through manufacturing partnerships.
Therapeutic oligonucleotides are a rapidly emerging class of drugs with transformative potential for rare and complex diseases, including neurodegenerative disorders, ophthalmic conditions, and cancer. While challenges such as in vivo stability and targeted delivery remain, these can be addressed through advanced chemical modifications. With over 30 years of expertise in oligonucleotide synthesis, metabion delivers highly customized, high-quality oligos tailored to the needs of researchers and developers. We support every stage of development, from early R&D to GMP(-like) manufacturing and clinical scale-up.
Product portfolio
Our portfolio covers the most prevalent types of therapeutic oligonucleotides:
- Antisense oligonucleotides (ASOs): Designed to specifically modulate gene expression
- siRNA: Small interfering RNAs for targeted gene silencing
- miRNA: MicroRNAs for regulating gene networks
- Gapmers/RNA-DNA Chimera: Chemically optimised for stability and efficacy
- Aptamers: Molecules that bind (protein) targets with high specificity
- Oligonucleotide Conjugates: Peptide, lipid, or sugar attachments for tissue-specific API/oligo delivery
- sgRNA for CRISPR/Cas technology: Supporting precise genome editing applications.
- Immunostimulant ONs/CpG oligonucleotides (ISOs): Tools to engage and modulate the immune system
Download our Brochure here
Modifications for therapeutic oligos
We offer a broad range of chemical modifications to optimise stability, efficacy, and tissue targeting of therapeutic oligos:
- Sugar modifications – e.g., LNA, 2´-F, 2´-OMe, 2´-MOE
- Backbone modifications – e.g., phosphorothioate (PTO)
- 5´ and internal modifications – e.g., 5mC, 5-hydroxyC, 8-bromoG, 8-aminoC, 2-thioT, GalNAc, cholesterol, PEG, peptide
- 3´ modifications – e.g., GalNAc, cholesterol, PEG, peptide
In collaboration with baseclick GmbH, we also provide a wide range of clickable modifications for tissue-specific targeting. Learn more about our partnership here.
Learn more about click chemistry in our Knowledge Hub.
Click Chemistry
Learn more about our cooperation with baseclick GmbH and how we can support your next generation therapeutics
Support and Services
We provide comprehensive support throughout the development and manufacturing of therapeutic oligonucleotides, from early research to clinical supply:
Process Development & Regulatory Support
- Design of Experiments (DOE)
- Process Characterization, Development, and Validation
- Support for IND and NDA filings
Analytical services
metabion offers an exhaustive panel of QC Analytical methods and services (to assess purity? Doublecheck with brochure)
Purity:
- UPLC/HPLC Identity by Mass Spectrometry (ESI)
- Appearance, pH, Osmolality
- Bioburden, Endotoxin level
- Phosphorothioate - Phosphate content
- Residual solvents, Residual heavy metals, Water content,
- Sodium content
- Stability studies
Custom formulation, Fill & Finish support and services
Extensive downstream processing equipment and capabilities
- Chromatography systems
- Ultrafiltration equipment
- Lyophilization services
- Liquid or powder filling
From Concept to Clinic: R&D to GMP grade manufacturing
Through collaborations with our partner Biospring GmbH, we support therapeutic oligonucleotide programs from your very first idea through to clinical development. We ensure smooth knowledge transfer and reliable GMP-grade scale-up, maintaining the highest quality standards. Our combined comprehensive capabilities mean you can always rely on a trusted partners for your oligonucleotide program at every stage.
Our combined expertise spans every stage of the journey: lead discovery and optimization, preclinical development, analytical characterization, process development, regulatory support, and upscaling for clinical trials.
For more details on the collaboration between BioSpring and metabion, please download our flyer.
Any Questions?
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