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Do I need to have my antisense/PTO purified?

Given the use of antisense oligos in cells and in vivo, high purity is essential.

High pressure liquid chromatography (HPLC) purification is standard (no additional charge) for antisense/PTOs. For applications in cells and in vivo, we recommend an additional Size-Exclusion Chromatography (SEC) purification. This is a size exclusion chromatography purification that removes salts and other small molecules, whose quantity and/or quality can be toxic for cells.