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Do I need to have my siRNA/RNAi/duplex RNA purified?

Given the use of siRNA oligos in cells and in vivo, high purity is essential.

High pressure liquid chromatography (HPLC) purification is standard (no additional charge) for siRNAs. For applications in cells and in vivo, we recommend an additional Size Exclusion Chromatography (SEC) purification. This is a purification that removes salts and other small molecules, whose quantity and/or quality can be toxic for cells.