7-deaza-dG

7-deaza-dG (Figure 1) can be inserted in an oligonucleotide to create an asymmetric base pair.
The Tm of the 7-deaza-dG: C binding is 1 °C lower, compared to the natural G: C binding. Therefore, replacing native Gs with 7-deaza-dG in GC-rich sequences can partially solve problems arising from G or GC-rich regions, such as formation of secondary structure.

Figure 1. Structure of 7-deaza-dG at the 5'-end (R = sequence).

metabion offers 7-deaza-dG as a modification in its RNA portfolio:

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References

1. Seela F., Driller H. Alternating d(G-C)3 and d(C-G)3 hexanucleotides containing 7-deaza-2'-deoxyguanosine or 8-aza-7-deaza-2'-deoxyguanosine in place of dG. Nucleic Acids Res. 1989 Feb 11;17(3):901-10.