8-oxo-dG

8-Oxo-dG stands (Figure 1) for 8-oxo-deoxyguanosine and it consists of an oxidized nucleotide, commonly used to study DNA damage following oxidative stress. In oxidative stress, reactive oxygen species (ROS) damage the DNA, thus creating 8-Oxo-dG “lesions”. 8-Oxo-dGs can create mismatches via pairing with A, thus leading to G → T transversion. In nature, 8-Oxo-dG does not appear to be highly mutagenic, as the base excision repair system usually restores 8-Oxo-dG to native G.

Figure 1. Structure of 8-Oxo-dG (R = sequence).

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References

1. Neeley WL., Essigmann JM. Mechanisms of formation, genotoxicity, and mutation of guanine oxidation products. Chem Res Toxicol. 2006 Apr;19(4):491-505.