Acrydite

AcryditeTM (Figure 1) consists of an acrylic phosphoramidite that covalently reacts with thiol-modified moieties. Acrydite-conjugated oligonucleotides can be incorporated into standard polyacrylamide gels, to capture complementary single-stranded nucleic acids during a gel run. This technology, called Hybridgel-like technology, is used to purify DNA.

Figure 1. Structure of 5'-Acrydite (R = sequence).

metabion offers Acrydite as a modification in its standard DNA portfolio:

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References

Rehman FN., Audeh M., Abrams ES., Hammond PW., Kenney M., Boles TC. Immobilization of acrylamide-modified oligonucleotides by co-polymerization. Nucleic Acids Res. 1999 Jan 15;27(2):649-55.