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Biotin (Figure 1) can be used as an oligonucleotide modification for a variety of assays. Moieties or surfaces conjugated with streptavidin will bind Biotin-labelled oligos tightly.

Figure 1. Structure of 5'-Biotin (R = sequence).

metabion offers Biotin as a 5'-, 3'- or internal modification in its standard DNA and RNA portfolio: