8-Bromo-deoxyguanine (Bromo-dG, Figure 1) is a halogenated nucleotide, commonly used in X-ray crystallography to facilitate the determination of DNA structure. Additionally, bromo nucleotides are photo-labile and therefore suitable for UV-crosslinking experiments to study protein-DNA complexes. 5-Br-dU was also used to create photo-aptamers able to crosslink with their target.
![](https://www.metabion.com/uploads/Bromo-dG.png.pagespeed.ce.vs6UJS4oXo.png)
Figure 1. Structure of 8-Bromo-deoxyguanine (R = sequence).
metabion offers the Bromo-dG modification in its DNA and RNA portfolio: