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C12-Amino (Figure 1) is useful to incorporate a primary amino group at the 5’ terminus of an oligonucleotide. A 12-carbon spacer arm separates the amino group from the oligonucleotide, thereby reducing steric interactions between the amino-moiety and the oligo itself. This modification allows the conjugation of the oligonucleotide with a variety of different moieties, like fluorescent dyes, quenchers, haptens, etc.

Figure 1. Structure of 5'-C12-Amino (R = sequence).

metabion offers C12-Amino as a modification in its standard DNA portfolio:

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