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C12 spacer

3'- spacers are often used as an alternative to 3'-phosphate as blockers; the most common is the C3 spacer. In general, a spacer is incorporated to add a distance between the oligo and a modifier. Spacers can be hydrophilic (e.g., the HEG spacer) or hydrophobic (C3 or C6 spacers).

The C12 spacer (Figure 1) consists of a 12-carbon spacer, useful to introduce a short spacer into an oligonucleotide.

Figure 1. Structure of the C12 spacer (R = sequence, B = base).

metabion offers the C12 spacer in its standard DNA portfolio:

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