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C6 spacer

3'- spacers are often used as an alternative to 3'-phosphate as blockers; the most common is the C3 spacer. In general, a spacer is incorporated to add a distance between the oligo and a modifier. Spacers can be hydrophilic (e.g., the HEG spacer) or hydrophobic (C3 or C6 spacers).

The C6 spacer consists of a 6-carbon spacer, useful to introduce a short spacer into an oligonucleotide (Figure 1).

Figure 1. Structure of the C6 spacer (R = sequence, B = base).

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