Cholesteryl-TEG (Figure 1) is often used to increase the cell uptake of oligonucleotide. This modification has been shown to elicit cell uptake both in vitro and in vivo (1).
![](https://www.metabion.com/uploads/5-Cholesteryl-TEG.png.pagespeed.ce.GcvyjJGoHP.png)
Figure 1. Structure of 5'-Cholesteryl-TEG (R = sequence).
metabion offers Cholesteryl-TEG in its standard DNA and RNA portfolio: