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DBCO-TEG (Figure 1) is usually used in copper-free click reactions, where DBCO-TEG-modified oligos and azide modifiers are conjugated in organic solvents, such as DMSO, or aqueous buffers. With DBCO-TEG, a TEG spacer separates the oligonucleotide from the DBCO, and from the Azide modifier, once the “click” reaction is complete. metabion offers DBCO-TEG as a modification in its DNA portfolio.

Figure 1. Structure of 5'-DBCO-TEG (R = sequence).

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van Delft P., Meeuwenoord NJ., Hoogendoorn S., Dinkelaar J., Overkleeft HS., van der Marel GA., Filippov DV. Synthesis of oligoribonucleic acid conjugates using a cyclooctyne phosphoramidite. Org Lett. 2010 Dec 3;12(23):5486-9.