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HEG spacer

3'- spacers are often used as an alternative to 3'-phosphate as blockers; the most common is the C3 spacer. In general, a spacer is incorporated to add a distance between the oligo and a modifier. Spacers can be hydrophilic (e.g., the HEG spacer) or hydrophobic (C3 or C6 spacers).

The HEG spacer (Figure 1) is an ethylene glycol-based chain. As such, this spacer is slightly more hydrophilic than C3 and C12 spacers.

Figure 1. Structure of the HEG spacer (R = sequence, B = base).

metabion offers the HEG spacer in its standard DNA portfolio:

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