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RNA oligos – single tube

With over 20 years of experience in oligo synthesis, metabion can provide you with a full range of RNA oligonucleotides and modifications of highest quality at competitive prices!

Our service at a glance:

  • We provide you with your specified oligos, as well as applying your choice from among a broad range of modifications;
  • For assistance with your order, you can always rely on our top quality Customer Service via chat, telephone or e-mail;
  • If you order within 6 pm CET/CEST, we start processing your order on the same day;
  • Unmodified and single-modified RNA oligos with HPLC purification will on average be shipped within 5-10 working days. Expected turnover time for desalted RNA oligonucleotides in single tube format is 3-5 days. 
  • You will receive your oligos dry. The synthesis report delivered with the order will give you information on the amount of water or buffer to be added to get a 100µM solution;
  • Synthesis of large-scale RNA oligos is also available;
  • RNA oligos can be ordered in distinct yield ranges, referring to the range of final yield you will get delivered;
  • All our RNA oligonucleotides are HPLC purified and checked for their quality with Mass spectrometry by default. Only RNA oligonucleotides up to 40 bases can be ordered desalted.

Any questions? Visit our FAQs page or contact us!

Our standard custom RNA - Portfolio


4 yield ranges based on length-independent delivered quantities from 10-100 nmol for single-stranded oligos from 5-40 nucleotides.

  • ≥  10 <   25 nmol
  • ≥  25 <   50 nmol
  • ≥  50 < 100 nmol
  • ≥ 100 nmol

5 yield ranges based on length independent delivered quantities from 5-400 nmol for single strand oligos from 2-80 nucleotides.

  • ≥     5 <   25 nmol
  • ≥   25 <   50 nmol
  • ≥   50 < 100 nmol
  • ≥ 100 < 200 nmol
  • ≥ 200 < 400 nmol

We offer

  • an extended standard selection of single modifications (5´, internal, 3´);
  • QC by Mass-Check for best quality;
  • delivery in single tubes under dry shipping conditions;
  • comprehensive and best value pricing scheme.

Fluorescent Modifications

Non-Fluorescent Modifications

FAQ – you ask, we answer


RNA duplexes are significantly more resistant to nucleases than a single strand RNA oligonucleotide. However, maintaining sterile, RNAse free conditions is always recommended as a precaution. Dried pellets are stable at room temperature for 2–4 weeks, but should be placed at –20 °C or –80 °C for long term storage. Under these conditions, dry RNA is stable for at least one year.


While some manufacturers state that re-annealing is generally not necessary, we do recommend to re-anneal the dissolved duplex using a suitable protocol. For your convenience, we recommend to follow our guidelines prepared for download.


There are two ways of ordering:

  1. The preferred way is order transmission through our Web Order Portal for most convenient online shopping (please refer here for further details).
  2. You can order by sending us an e-mail at with our pre-formatted excel order file as attachment. Download respective Order Form.

When you write your e-mail, please make sure to include the following required information in the excel template:

  1. Name of the RNA oligo/s.
  2. Sequence of the RNA oligo/s in 5’-3’ orientation. 
  3. Yield range.
  4. Purification required.
  5. Modifications.

If you are a new customer, please additionally provide us with:

  1. Your shipping and billing address.
  2. Any other information like Purchase Order number, VAT number (VAT only for customers resident in the EU), etc.

In case you choose to transmit orders via e-mail using your own format(s), we need to alert you that above mentioned information in bold print is obligatory for processing your order. Due to extra efforts necessary for individual order format transfer into our system, order processing will take longer as compared to preferred web orders and pre-formatted e-mails. Please note that only files updated to the latest excel/word version (e.g. .xlsx or .docx) are accepted.

How can you convert files to newer formats?
Open the file in a recent Office program and save the file in a newer format. For this go to “File” → “Save as” and choose the newer format from the “Save as type” dropdown menu.

If you want to connect your eProcurement System with our Web Order Portal (e.g. OCI - Open Catalog Interface), please simply contact our Customer Service (


4 yield ranges based on length-independent delivered quantities from 10-100 nmol for single-stranded oligos from 5-40 nucleotides.

  • ≥ 10 <   25 nmol
  • ≥ 25 <   50 nmol
  • ≥ 50 < 100 nmol
  • ≥ 100 nmol

5 yield ranges based on length independent delivered quantities* from 5-400 nmol for oligos from 2-80 nucleotides:

  • ≥    5 <    25 nmol
  • ≥   25 <   50 nmol
  • ≥   50 < 100 nmol
  • ≥ 100 < 200 nmol
  • ≥ 200 < 400 nmol

* Please note that the term “yield range” refers to the final amount of product you will actually receive. Instead, OD260 values are a measure of total nucleotide optical density. Hence, neither purity nor amount of ordered substance are transparently reflected. For simplification and exemplification reasons look at the following:

1 OD of the 20mer 5´cau cgu auu cga ugc uac gu 3´ translates into approximately 5 nmol;

1 OD of the 40mer 5´cau cgu auu cga ugc uac guc auc gua uuc gau gcu acg u 3´ translates into approximately 2.5 nmol.

Therefore, a 1 OD guaranteed amount of delivered product can vary significantly, while metabion´s commitment to delivered yields in nmol for RNAs ranging from 2 to 80 nucleotides does not allow for ambiguity in terms of what you expect and pay for, not even for modified oligos!


The current maximum length of standard RNA oligonucleotides is 140 bases. For RNA oligos longer than 140 bases, please inquire.


For details please click here.


Yes, we do! This is part of our standard RNA portfolio! Delivery/shipping condition of dsRNA like for all our RNA oligos is “dry”. Simply dissolve the pellet in annealing buffer and apply a suitable annealing protocol. For your convenience we recommend to follow our guidelines on our download section.


Expected turnover time for:

  • desalted RNA oligonucleotide in single tube format is 3–5 days;
  • RNA in plates, expected turnover time is 5–7 business days*;
  • HPLC-purified, unmodified or single-labelled RNA oligonucleotides from our standard portfolio are usually processed within 5–10 business days including purification and quality control*;
  • duplex oligos take about 10–15 days to be produced, purified and QCed*;
  • for RNA dlps you should consider 10–15 days as a realistic turnaround time and for RNA longmers depending on sequence length/complexity and modification level 8-15 business days*.

*Freight forwarders delivery time to the final destination is not included in all cases. In terms of "counting" working days, orders placed past 15:00 (Munich time) are considered to be next day's order. Be assured that we try to process your order as quickly as possible without compromising on quality!


Synthesis is monitored through trityl analysis. Quality check by mass spectrometry further ensure top quality. Please visit our FAQs page for more information.


For desalted RNAs falling into the specifications of our standard portfolio, you can expect at least >80% of purity. HPLC-purified RNAs falling within the specifications of our standard portfolio, have typical purity >85%. Please note that most delivered RNAs will have purities >90%.


All oligonucleotides, whether single-stranded or double-stranded oligos, are provided as dried pellets and shipped at ambient temperature. While being stable at room temperature for 2–4 weeks, they should be placed at –20 °C or at lower temperature upon receipt.